Over three weeks ago, hydroxychloroquine was all the rage in MAGA world, despite flawed and scattered evidence about whether the drug could help cure coronavirus. Now there is another drug, remdesivir, with positive early scientific data.

Much of MAGA world wants little to do with it.

At first, it may seem like a head-scratching response. President Donald Trump’s base has been quick to trumpet any potential solutions to the coronavirus pandemic — especially those Trump himself promotes — regardless of the red flags from medical experts. But with remdesivir, it’s the Trump-boosting pundits who are raising the red flags, even as the president expresses optimism.

Indeed, the same segment of the right that claimed scientists and the media were deliberately downplaying hydroxychloroquine in order to hurt Trump’s standing are now the ones downplaying remdesivir. On Fox News, Laura Ingraham suggested that remdesivir, as a newer drug being produced by the pharmaceutical company Gilead Sciences, could be unsafe and expensive. Those who initially helped raise the profile of hydroxychloroquine raised doubts about the remdesivir studies.

The unexpected reaction appears to stem from the differences in how the two drugs came into the public spotlight. Hydroxychloroquine bubbled up through the MAGA grassroots — little-known investors promoted it online, got on Fox News and suddenly the president was talking about it from the White House. Remdesivir’s progress came through a government-funded trial that had the blessing of Dr. Anthony Fauci, the bête noire of Trump hardliners who blame the government’s top infectious disease expert for undermining the president and causing unnecessary economic damage with his social-distancing guidelines.Remdesivir’s connection to a pharmaceutical company also taps into suspicions on the right that corporate executives are trying to rake in huge profits from the coronavirus. Hydroxychloroquine, on the other hand, is already widely available in generic form.

These factors were likely enough to turn off people who had been using hydroxychloroquine as a political rallying cry, said David Rapp, a psychology professor at Northwestern University who studies how misinformation shapes beliefs and memory.

The hydroxychloroquine boosters, he said, “might find the alternative idea as not being pure, in the sense that it doesn’t come from Trump. It’s coming from other sources that they might not trust.”

The MAGA base’s suspicions about remdesivir began shortly after Fauci on Wednesday announced the results of a government-sponsored clinical trial that showed that the drug shortened recovery time for coronavirus patients, calling it a “clear-cut, positive” development in the fight against the coronavirus. Fauci also made clear that this is a first step; more research needs to be done into this and other potential treatments.

That night, Ingraham devoted a segment of her show that night arguing on behalf of hydroxychloroquine. Ingraham first suggested that remdesivir could present dangers, urging restraint until government regulators like the Food and Drug Administration could thoroughly review the treatment.

“It hasn’t been approved by the FDA,” she said. “They might do emergency authorization. Hydroxychloroquine was approved decades ago.”

The FDA — which Fauci does not run — in fact did move swiftly. On Friday it issued an emergency-use authorization to help patients get quicker access to remdesivir, the first antiviral to show promise against Covid-19 infection.

Ingraham added that remdesivir, as a new drug, could be expensive, whereas “hydroxychloroquine is obviously cheap and already readily available.” She then brought out a doctor who defended hydroxychloroquine as “safe” and expressed worries that remdesivir, originally developed to fight Ebola, could be dangerous.

The original promoters of hydroxychloroquine also chimed in with their concerns about remdesivir after Fauci’s announcement. James Todaro, a bitcoin investor who cobbled together a Google Doc pitching hydroxychloroquine as a coronavirus treatment that was widely circulated in conservative circles and caught the attention of Fox News, noted that several members on the government panel making treatment recommendations for coronavirus were affiliated with Gilead.