NEW YORK (AP) — U.S. deaths from the coronavirus pandemic have topped 1,000, in another grim milestone for a global outbreak that is taking lives and wreaking havoc on economies and established routines of ordinary life.

In a recognition of the scale of the threat, the U.S. Senate late Wednesday passed an unparalleled $2.2 trillion economic rescue package steering aid to businesses, workers and health care systems.

The unanimous vote came despite misgivings on both sides about whether it goes too far or not far enough and capped days of difficult negotiations as Washington confronted a national challenge unlike it has ever faced. The 880-page measure is the largest economic relief bill in U.S. history.

Worldwide, the death toll climbed past 21,000, according to a running count kept by Johns Hopkins University. The number of dead in the U.S. rose to 1,041 as of late Wednesday, with nearly 70,000 infections.

Spain’s death toll has risen past 3,400, eclipsing that of China where the virus was first detected in December, after a one-day spike of 700 fatalities. Spain’s count is now second only to that of Italy, with over 7,500 deaths. Lidia Perera, a nurse at Madrid’s 1,000-bed Hospital de la Paz, said more workers were desperately needed. “We are collapsing,” Perera said.

The Spanish parliament voted to allow the government extend strict stay-at-home rules and business closings until April 11.

Such measures are becoming increasingly common in the U.S., where New York is the current epicenter of the domestic outbreak, accounting for more than 30,000 cases and close to 300 deaths, most of them in New York City.

Public health officials in the city hunted down beds and medical equipment and put out a call for more doctors and nurses for fear the number of sick will explode in a matter of weeks, overwhelming hospitals as has happened in Italy and Spain.

A makeshift morgue was set up outside Bellevue Hospital, and the city’s police, their ranks dwindling as more fall ill, were told to patrol nearly empty streets to enforce social distancing. Another was erected outside a hospital in Elmhurst, Queens: