Large parts of the eastern United States will wake up to snow from a major winter storm that dumped more than a foot in parts of Pennsylvania, led to hundreds of car crashes and is suspected in the deaths of at least three people.

More than 6 inches of snow and sleet covered New York’s Central Park as of midnight, surpassing the 4.8 inches that fell all last winter, the National Weather Service said. Lanes on the Henry Hudson Bridge had been closed after a 19-car collision amid the storm, according to the NYPD, which urged people to stay home.

Parts of Central Pennsylvania saw more than a foot Wednesday. A crash on Interstate 80 in Clinton County involving dozens of vehicles killed two people, and weather was a factor, state police said.

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As the storm swept north Wednesday, Virginia State Police responded to approximately 200 crashes and 125 disabled or stuck vehicles. One of those crashes in Pulaski County killed a 19-year-old North Carolina man, a police spokeswoman said.

“We’re obviously asking people to stay off the roads,” said Massachusetts Gov. Charlie Barker, whose state was forecast to get a foot or more of snow, at a Wednesday briefing.

Boston is expected to get 8 to 12 inches, with the heaviest snow likely between midnight and 7 a.m. Thursday, said Torry Gaucher, a meteorologist with the National Weather Service. Lingering snow showers should move out of the area by Thursday evening or night, he said.